VU6077564 | mAChR M1 antagonist | Probechem Biochemicals

Chemical Structure : VU6077564

VU6077564 (VU 6077564, VU-6077564)

Catalog No.: PC-27274Not For Human Use, Lab Use Only.

VU6077564 is a peripherally restricted and selective mAChR M1 antagonist with IC50 of 31 nM (hM1), >300-fold selective over hM2.

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Biological Activity

VU6077564 is a peripherally restricted and selective mAChR M1 antagonist with IC50 of 31 nM (hM1), >300-fold selective over hM2.
VU6077564 exhibits potent KB value of 30 nM for human M1.
VU6077564 increases neurite outgrowth of adult rat sensory neurons with ED50 of 55 nM.

Physicochemical Properties

M.Wt	522.60
Formula	C26H27FN6O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1R,3s)-3-((S)-4-(5-Cyano-6-methylpyridin-2-yl)-2-methylpiperazine-1-carbonyl)cyclobutyl)-8-fluoroquinoline-5-sulfonamide

References

1. Tomayo I Berida, et al. ACS Chem Neurosci. 2026 Jul 7. doi: 10.1021/acschemneuro.6c00367.

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VU6077564 (VU 6077564, VU-6077564)

Biological Activity

Physicochemical Properties

References

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