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Chemical Structure : VX-148
Catalog No.: PC-35012Not For Human Use, Lab Use Only.
VX-148 is a potent, uncompetitive, orally bioavailable IMPDH inhibitor with Ki of 6 nM against IMPDH type II enzyme.
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VX-148 is a potent, uncompetitive, orally bioavailable IMPDH inhibitor with Ki of 6 nM against IMPDH type II enzyme; VX-148 is slightly more potent than VX-497 in inhibiting the proliferation of mitogen-stimulated primary human lymphocytes (IC50=80 nM); inhibits primary antibody response in mice with ED50 value of 38 mg/kg b.i.d, significantly prolongs skin graft survival at 100 mg/kg b.i.d.
Psoriasis
Discontinued
| M.Wt | 435.48 | |
| Formula | C23H25N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jain J, et al. J Pharmacol Exp Ther. 2002 Sep;302(3):1272-7.
2. Dunkern T, et al. J Enzyme Inhib Med Chem. 2014 Jun;29(3):408-19.
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