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Vacquinol-1

Chemical Structure : Vacquinol-1

CAS No.: 5428-80-8

Vacquinol-1 (NSC 13316)

Catalog No.: PC-62664Not For Human Use, Lab Use Only.

Vacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells.

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    Biological Activity

    Vacquinol-1 (NSC 13316) is a MKK4 (MAP2K4, MEK4) activator that induces vacuolization, induces ATP depletion in glioblastoma cells (IC50 = 3.14 uM) without affecting fibroblasts, embryonic stem cells, or osteosarcoma cells; induces rapid and specific cell death of glioma cells via membrane ruffling, cell rounding, massive macropinocytic vacuole accumulation, ATP depletion, and cytoplasmic membrane rupture; shows good brain penetrance and excellent pharmacokinetics; orally bioactive.

    Physicochemical Properties

    M.Wt 352.862
    Formula C21H21ClN2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    [2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol

    References

    1. Kitambi SS, et al. Cell. 2014 Apr 10;157(2):313-28.

    2. Hammarström LG, et al. J Med Chem. 2016 Sep 22;59(18):8577-92.

    3. Sander P, et al. Oncotarget. 2017 May 23;8(21):35124-35137.

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