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Chemical Structure : Vamorolone
Catalog No.: PC-35648Not For Human Use, Lab Use Only.
Vamorolone (VBP-15) is a dissociative steroidal compound, reduces NF-κB-mediated cytokine expression in vitro, alsp reduecs glucocorticoid-mediated side-effects when compared to dexamethasone in vivo.
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Vamorolone (VBP-15) is a dissociative steroidal compound, reduces NF-κB-mediated cytokine expression in vitro, alsp reduecs glucocorticoid-mediated side-effects when compared to dexamethasone in vivo; reduces NF-κB pathway inflammatory cytokines in mouse primary DIPG cells, shows efficacy in inducing an anti-inflammatory response in animal models of asthma, multiple sclerosis, inflammatory bowel disease, and muscular dystrophies, and has shown fewer side effects; increases physical activity of tumor bearing mice.
| M.Wt | 356.462 | |
| Formula | C22H28O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wells E, et al. Oncotarget. 2017 Feb 7;8(6):9366-9374.
2. Conklin LS, et al. Pharmacol Res. 2018 Sep 13;136:140-150.
3. Hoffman EP, et al. Steroids. 2018 Jun;134:43-52.
4. Almeida LEF, et al. Sci Rep. 2018 Apr 17;8(1):6081.
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