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Chemical Structure : Vandetanib
CAS No.: 443913-73-3
Catalog No.: PC-42496Not For Human Use, Lab Use Only.
Vandetanib (ZD6474) is a potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $118 | In stock | |
| 100 mg | $178 | In stock | |
| 200 mg | $278 | In stock | |
| 1 g | Get quote |
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Vandetanib (ZD6474) is a potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM.
Vandetanib (ZD6474) shows weak inhibition for VEGFR3 and EGFR (IC50 is 100 nM and 500 nM respectively).
Vandetanib (ZD6474) displays excellent selectivity over erbB2, MEK, CDK-2, Tie-2, IGFR-1R, PDK, PDGFRβ, and Akt (IC50=1.1-100 uM).
Vandetanib (ZD6474) has excellent solubility and good oral bioavailability.
| M.Wt | 475.354 | |
| Formula | C22H24BrFN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 27.5 mg/mL |
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| Chemical Name/SMILES |
4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]- |
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1. Hennequin LF, et al. J Med Chem. 2002 Mar 14;45(6):1300-12.
2. Wedge SR, et al. Cancer Res. 2002 Aug 15;62(16):4645-55.
3. Carlomagno F, et al. Cancer Res. 2002 Dec 15;62(24):7284-90.
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