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Chemical Structure : Vandetanib hydrochloride
Catalog No.: PC-42498Not For Human Use, Lab Use Only.
Vandetanib hydrochloride is a potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM.
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Vandetanib hydrochloride is a potent and selective VEGFR2 (KDR) inhibitor with IC50 of 40 nM.
Vandetanib shows weak inhibition for VEGFR3 and EGFR (IC50 is 100 nM and 500 nM respectively).
Vandetanib displays excellent selectivity over erbB2, MEK, CDK-2, Tie-2, IGFR-1R, PDK, PDGFRβ, and Akt (IC50=1.1-100 uM).
Vandetanib has excellent solubility and good oral bioavailability.
| M.Wt | 511.8149 | |
| Formula | C22H25BrClFN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hennequin LF, et al. J Med Chem. 2002 Mar 14;45(6):1300-12.
2. Wedge SR, et al. Cancer Res. 2002 Aug 15;62(16):4645-55.
3. Carlomagno F, et al. Cancer Res. 2002 Dec 15;62(24):7284-90.
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