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Chemical Structure : Varespladib
CAS No.: 172732-68-2
Catalog No.: PC-43510Not For Human Use, Lab Use Only.
Varespladib (LY315920, A-002) is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2) with IC50 of 9 nM, 40-fold less active against group IB, pancreatic sPLA2 and inactive against cytosolic PLA2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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Varespladib (LY315920, A-002) is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2) with IC50 of 9 nM, 40-fold less active against group IB, pancreatic sPLA2 and inactive against cytosolic PLA2.
Varespladib (LY315920, A-002) inhibits human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells with IC50 of 0.79 uM.
Varespladib (LY315920, A-002) suppresses sPLA2 produced contractile responses in guinea pig lung pleural strips with KB of 83 nM.
Varespladib (LY315920, A-002) reduces atherosclerosis and aneurysm formation in ApoE-/- mice.
| M.Wt | 380.39 | |
| Formula | C21H20N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
Acetic acid, 2-[[3-(2-amino-2-oxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]- |
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1. Snyder DW, et al. J Pharmacol Exp Ther. 1999 Mar;288(3):1117-24.
2. Draheim SE, et al. J Med Chem. 1996 Dec 20;39(26):5159-75.
3. Fraser H, et al. J Cardiovasc Pharmacol. 2009 Jan;53(1):60-5.
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