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Velcalcetide

Chemical Structure Velcalcetide

CAS No.: 1262780-97-1

Velcalcetide (AMG-416;AMG416;Etelcalcetide;KAI-4169)

Catalog No.: PC-63560Not For Human Use, Lab Use Only.

Velcalcetide (AMG-416, Velcalcetide, Etelcalcetide, KAI-4169) is a potent, peptide agonist of CaSR, dose-dependenty increases IP1 accumulation with EC50 of 25 uM in cell based assays.

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5 mg $368 In stock
25 mg $748 In stock
100 mg $1480 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Velcalcetide (AMG-416, Velcalcetide, Etelcalcetide, KAI-4169) is a potent, peptide agonist of CaSR, dose-dependenty increases IP1 accumulation with EC50 of 25 uM in cell based assays; reduces parathyroid hormone (PTH) levels and corresponding decreases serum calcium, regardless of the baseline level of PTH in vivo.

Hyperparathyroidism

Approved

Physicochemical Properties

M.Wt 1048.259
Formula C38H73N21O10S2
CAS No. 1262780-97-1
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name

S-(((S)-2-acetamido-3-(((R)-1-(((R)-1-(((R)-1-(((R)-1-(((R)-1-(((R)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-1-oxopropan

Clinical Information

References

1. Walter S, et al. J Pharmacol Exp Ther. 2013 Aug;346(2):229-40.

2. Martin KJ, et al. Kidney Int. 2014 Jan;85(1):191-7.

3. Walter S, et al. BMC Nephrol. 2014 May 19;15:81.

4. Martin KJ, et al. Nephrol Dial Transplant. 2014 Feb;29(2):385-92.

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