Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Venadaparib
CAS No.: 1681017-83-3
Catalog No.: PC-38102Not For Human Use, Lab Use Only.
Venadaparib (IDX-1197) is a potent, selective PARP inhibitor with IC50 of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | $958 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Venadaparib (IDX-1197) is a potent, selective PARP inhibitor with IC50 of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively.
IDX-1197 does not inhibits PARP5A (Tankyrase-1, IC50>10 uM), which belongs to the PARP family.
IDX-1197 significantly inhibited PARP1-mediated PAR expression in DNA damage-induced Hela cells.
IDX-1197 exhibits potent tumor growth inhibition in germline BRCA1-mutated ovarian cancer PDX model.
IDX-1197 shows improved antitumor activity against breast cancer PDX models, which included both germline BRCA-mutated and non-germline BRCA-mutated models, compared with olaparib and/or niraparib.
| M.Wt | 406.461 | |
| Formula | C23H23FN4O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-(3-(3-((cyclopropylamino)methyl)azetidine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one |
|
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
