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Verosudil

Chemical Structure : Verosudil

CAS No.: 1414854-42-4

Verosudil ( AR-12286)

Catalog No.: PC-62715Not For Human Use, Lab Use Only.

Verosudil (AR-12286) is a potent ROCK inhibitor (Ki=0.2 nM) that effectively lowers intraocular pressure (IOP) in animal models and human subjects .

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Verosudil (AR-12286) is a potent ROCK inhibitor (Ki=0.2 nM) that effectively lowers intraocular pressure (IOP) in animal models and human subjects

Other Indication

Phase 2 Discontinued

Physicochemical Properties

M.Wt 327.402
Formula C17H17N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(dimethylamino)-N-(1-oxo- 1,2-dihydroisoquinolin-6-yl)-2-(thiophen-3-yl)acetamide

References

1. Sturdivant JM, et al. Bioorg Med Chem Lett. 2016 May 15;26(10):2475-80.

2. Kopczynski C, et al. Br J Ophthalmol. 2013 May;97(5):567-72.

3. Williams RD, et al. Am J Ophthalmol. 2011 Nov;152(5):834-41.e1.

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