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Chemical Structure : Volasertib
CAS No.: 755038-65-4
Catalog No.: PC-42899Not For Human Use, Lab Use Only.
Volasertib (BI 6727) is a potent, selective Polo-like kinase (PLK) inhibitor with IC50 of 0.87, 5 and 56 nM for PLK1, 2 and 3, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | $558 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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Volasertib (BI 6727) is a potent, selective Polo-like kinase (PLK) inhibitor with IC50 of 0.87, 5 and 56 nM for PLK1, 2 and 3, respectively.
Volasertib (BI 6727) displays no inhibitory activity against a panel of >50 other kinases.
Volasertib (BI 6727) inhibits proliferation of multiple cell lines derived from various cancer tissues, including HCT116 (EC50=23 nM) and NCI-H460 (EC50=21 nM),BRO (EC50=11 nM), and hematopoietic cancer cell HL-60 (EC50=32 nM).
Volasertib (BI 6727) demonstrates marked antitumor activity in multiple cancer models, including a model of taxane-resistant colorectal cancer.
| M.Wt | 618.8126 | |
| Formula | C34H50N8O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy- |
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1. Rudolph D, et al. Clin Cancer Res. 2009 May 1;15(9):3094-102.
2. Grinshtein N, et al. Cancer Res. 2011 Feb 15;71(4):1385-95.
3. Schöffski P, et al. Eur J Cancer. 2012 Jan;48(2):179-86.
4. Sanhaji M, et al. Cell Cycle. 2012 Feb 1;11(3):543-53.
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