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Chemical Structure : Vps34 inhibitor PIK-III
CAS No.: 1383716-40-2
Catalog No.: PC-43213Not For Human Use, Lab Use Only.
Vps34 inhibitor PIK-III (PIK-III) is a potent, selective inhibitor of Vps34 with IC50 of 18 nM, shows >100-fold selectivity over other class I PI3Ks, PI4Kβ and mTOR.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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Vps34 inhibitor PIK-III (PIK-III) is a potent, selective inhibitor of Vps34 with IC50 of 18 nM, shows >100-fold selectivity over other class I PI3Ks, PI4Kβ and mTOR.
Vps34 inhibitor PIK-III inhibits the localization of GFP-FYVE in mammalian cells with IC50 of 55 nM, which is >10,000 times more potent than the non-selective VPS34 inhibitor 3-MA.
Vps34 inhibitor PIK-III robustly inhibits autophagy and LC3 lipidation, leads to the stabilization of autophagy substrates in mammalian cells.
| M.Wt | 319.3638 | |
| Formula | C17H17N7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
[4,5'-Bipyrimidine]-2,2'-diamine, 4'-(cyclopropylmethyl)-N2-4-pyridinyl- |
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1. Dowdle WE, et al. Nat Cell Biol. 2014 Nov;16(11):1069-79.
2. Honda A, et al. ACS Med Chem Lett. 2015 Nov 13;7(1):72-6.
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