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Chemical Structure : WAY-169916
CAS No.: 669764-18-5
Catalog No.: PC-38514Not For Human Use, Lab Use Only.
WAY-169916 is an orally active pathway-selective estrogen receptor (ER) ligand, inhibiting NF-kB transcriptional activity (IC50=93 nM), but is devoid of conventional estrogenic activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | $788 | In stock | |
| 1 g | Get quote |
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WAY-169916 is an orally active pathway-selective estrogen receptor (ER) ligand, inhibiting NF-kB transcriptional activity (IC50=93 nM), but is devoid of conventional estrogenic activity.
WAY-169916 does not promote the classic actions of estrogens such as stimulation of uterine proliferation or ER-mediated gene expression.
WAY-169916 is a potent antiinflammatory agent, as demonstrated in the HLA-B27 transgenic rat model of inflammatory bowel disease.
WAY-169916 inhibits nuclear factor-kappa B transcriptional activity in models of rheumatoid arthritis.
| M.Wt | 362.352 | |
| Formula | C19H17F3N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(1-Allyl-7-(trifluoromethyl)-1H-indazol-3-yl)benzene-1,3-diol |
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1. Steffan RJ, et al. J Med Chem. 2004 Dec 16;47(26):6435-8.
2. Chadwick CC, et al. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2543-8.
3. Keith JC Jr, et al. Arthritis Res Ther. 2005;7(3):R427-38.
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