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WAY-267464

Chemical Structure : WAY-267464

CAS No.: 847375-16-0

WAY-267464 (WAY267464)

Catalog No.: PC-27264Not For Human Use, Lab Use Only.

WAY-267464 (WAY267464) is a potent, selective, non-peptide oxytocin receptor (OXTR) agonist with Ki of 58.4 nM, >100-fold selectivity over V1a, V2, V1b receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

WAY-267464 (WAY267464) is a potent, selective, non-peptide oxytocin receptor (OXTR) agonist with Ki of 58.4 nM, >100-fold selectivity over V1a, V2, V1b receptors.
WAY-267464 exhibits an anxiolytic-like profile similar to oxytocin (OT), also significantly reverses disruption in prepulse inhibition of the acoustic startle reflex induced by either MK-801 or amphetamine in vivo.

Physicochemical Properties

M.Wt 581.68
Formula C32H35N7O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(3,5-Dihydroxy-benzyl)-piperazine-1-carboxylic acid 2-methyl-4-(3-methyl-4,10-dihydro-3H-2,3,4,9-tetraaza-benzo[f]azulene-9-carbonyl)-benzylamide

References

1. Ring RH, et al. Neuropharmacology. 2010 Jan;58(1):69-77.

2. Hicks C, et al. J Neuroendocrinol. 2012 Jul;24(7):1012-29.

3. Hicks C, et al. Br J Pharmacol. 2014 Jun;171(11):2868-87.

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