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Chemical Structure : WC36
Catalog No.: PC-49383Not For Human Use, Lab Use Only.
WC36 is a potent, specific inhibitor of Syk-cSH2 with IC50 of 40 nM, inhibits Syk-cSH2-PIP3 binding, specifically and potently suppresses oncogenic activities of Syk in AML cells.
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WC36 is a potent, specific inhibitor of Syk-cSH2 with IC50 of 40 nM, inhibits Syk-cSH2-PIP3 binding, specifically and potently suppresses oncogenic activities of Syk in AML cells.
WC36 potently blocks BCR-mediated activation of Syk in B cells, effectively suppresses phosphorylation of all BCR signaling proteins.
WC36 does not inhibit binding of ZAP-70-cSH2 to PIP3-containing vesicles, showing selectivity for Syk-cSH2 over ZAP-70-cSH2.
WC36 (5 uM) potently suppressed the phosphorylation and activation of Syk, ERK1/2 and STAT3/5 in entospletinib-resistant MV4-11 cells, but not 5 μM entospletinib.
WC36 potently inhibited proliferation of entospletinib-resistant MV4-11 cells.
WC36 suppressed HL-60 and patient-derived AML cells, while entospletinib was ineffective, WC36 potently inhibited phosphorylation of Syk, ERK1/2 and STAT3/5 in AML cells.
WC36 blocks not only the Syk kinase activity, but also its noncatalytic scaffolding function that is linked to drug resistance.
| M.Wt | 390.447 | |
| Formula | C21H22N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Indira Singaram, et al. Nat Chem Biol. 2022 Oct 13. doi: 10.1038/s41589-022-01150-z.
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