WC593

Chemical Structure : WC593

Catalog No.: PC-24368Not For Human Use, Lab Use Only.

WC593 is a potent pan-dishevelled (Dvl) inhibitor, blocks Wnt–β-catenin signaling and CRC cell proliferation.

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Biological Activity

WC593 is a potent pan-dishevelled (Dvl) inhibitor, blocks Wnt–β-catenin signaling and CRC cell proliferation.
WC593 potently inhibited β-catenin stability and β-catenin transcriptional activity in HCT15 and Caco2 cells.
WC593 is effective against Wnt3a-stimulated β-catenin signaling in all tested APC-truncated CRC cells, fully suppressing the signaling activity to the basal level.
WC593 potently suppressed the level of active β-catenin in those cells expressing APC truncations, ranging from APC1–331 to APC1–1941.
WC593 blocks CRC cell proliferation.

Physicochemical Properties

M.Wt	501.52
Formula	C23H26F3NO6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 4'-(dipropylcarbamoyl)-4-(((trifluoromethyl)sulfonyl)oxy)-[1,1'-biphenyl]-2-carboxylate

References

1. Sharma A, et al. Nat Chem Biol. 2025 Apr 16. doi: 10.1038/s41589-025-01870-y.

WC593

Biological Activity

Physicochemical Properties

References

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