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Chemical Structure : WEHI-518
Catalog No.: PC-21094Not For Human Use, Lab Use Only.
WEHI-518 is a small molecule inhibitor of the parasite's phosphatidylinositol kinase PfPI4KIIIB, shows EC50 of 22 nM against blood-stage P. falciparum parasites.
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WEHI-518 is a small molecule inhibitor of the parasite's phosphatidylinositol kinase PfPI4KIIIB, shows EC50 of 22 nM against blood-stage P. falciparum parasites.
WEHI-518 targets multiple stages of the asexual blood stage cell cycle, blocks invasion/early ring-stage development, does not inhibit parasite egress.
WEHI-518 (200 nM) reduces protein secretion and export in P. falciparum.
| M.Wt | 448.53 | |
| Formula | C28H24N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dawson B Ling, et al. ACS Infect Dis. 2023 Sep 8;9(9):1695-1710.
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