Chemical Structure : WEHI-P8
CAS No.:
WEHI-P8
Catalog No.: PC-24428Not For Human Use, Lab Use Only.
WEHI-P8 is a highly potent, specific, orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor with IC50 of 12 nM and KD of 9 nM, cellular EC50 of 298 nM in in-cell FRET-based biosensor assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
WEHI-P8 is a highly potent, specific, orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor with IC50 of 12 nM and KD of 9 nM, cellular EC50 of 298 nM in in-cell FRET-based biosensor assays.
WEHI-P4 displays suitable in vitro PK properties, including low hERG binding (IC50 = 5.39 µM), and good selectivity against 7 CYPs (IC50 = > 20 µM, 1A2, 2B6, 2C8, 2C9, 2C19, 3A4/5; 13.8 µM 2D6).
WEHI-P8 displayed an antiviral EC50 of 360 nM in Vero plaque assays.
WEHI-P8 (150 mg/kg) improves disease outcome in an acute mouse model of severe disease.
WEHI-P8 prevents severe outcomes in a model of severe SARS-CoV-2 disease, is more effective than PLT (Paxlovid-like treatment) at reducing viral burdens in 6–7-week-old mice infected with SARS-CoV-2 P21.
WEHI-P8 significantly reduces post-acute manifestations of disease in lungs and brain.
Physicochemical Properties
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M.Wt
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410.56
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Formula
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C25H34N2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-((R)-1-((1s,4S)-4-hydroxycyclohexyl)piperidin-3-yl)(6-methoxynaphthalen-2-yl)methanone O-ethyl oxime
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References
1. M Bader S, et al. Nat Commun. 2025 Apr 3;16(1):2900.
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