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Chemical Structure : WF-210
Catalog No.: PC-62211Not For Human Use, Lab Use Only.
WF-210 is a PAC-1 derivative and potent activator of procaspases-3 with EC50 of 0.95 uM, displays more cytotoxic than PAC‐1 to human cancer cells, but less cytotoxic to normal cells.
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WF-210 is a PAC-1 derivative and potent activator of procaspases-3 with EC50 of 0.95 uM, displays more cytotoxic than PAC‐1 to human cancer cells, but less cytotoxic to normal cells; exhibits an enhanced zinc chelating ability (EC50=2.88 uM) compared to PAC‐1, activates procaspase-3 through relief of zinc-mediated inhibition; more potently induces cancer cell death in vitro with mean IC50 of 0.88 uM against 15 cancer cell lines, induces apoptosis in HL-60 and U-937 cells via a caspase-dependent pathway, activates procaspase-3, reduces IAPs, and inhibits tumor growth in breast, liver, and gallbladder xenograft tumor models.
| M.Wt | 791.855 | |
| Formula | C41H38FN7O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang F, et al. Eur J Pharmacol. 2018 Feb 15;821:29-38.
2. Wang F, et al. Mol Oncol. 2014 Dec;8(8):1640-52.
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