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Chemical Structure : WM-3835
CAS No.: 2229025-70-9
Catalog No.: PC-38289Not For Human Use, Lab Use Only.
WM-3835 (WM 3835) is a potent, high-specific, cell-permeable inhibitor of MYST acetyltransferase HBO1 (KAT7 or MYST2).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $388 | In stock | |
| 100 mg | $628 | In stock | |
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WM-3835 (WM 3835) is a potent, high-specific, cell-permeable inhibitor of MYST acetyltransferase HBO1 (KAT7 or MYST2).
WM-3835 showed increased potency against HBO1 compared to WM-1119.
Treatment of a diverse set of AML cell lines with WM-3835 resulted in a marked reduction in tumour-cell viability, with an excellent dose-response relationship between a reduction of levels of H3K14ac,.
Treatment of cells with WM-3835 phenocopied the molecular and cellular effects of genetic depletion of HBO1 by inducing apoptosis, a G0/G1 cell-cycle arrest, differentiation of human AML cells and transcriptional repression on HOXA9 and HOXA10.
Inhibition of HBO1 phenocopied our genetic data and showed efficacy in a broad range of human cell lines and primary AML cells from patients.
| M.Wt | 400.42 | |
| Formula | C20H17FN2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-3-hydroxybenzenesulfonohydrazide |
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1. Laura MacPherson, et al. Nature. 2020 Jan;577(7789):266-270.
2. Yan-Yang Gao, et al. Theranostics. 2021 Mar 4;11(10):4599-4615.
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