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Chemical Structure : WNK463
CAS No.: 2012607-27-9
Catalog No.: PC-42214Not For Human Use, Lab Use Only.
The first, potent, selective, and orally bioavailable pan With-No-Lysine (WNK) Kinase catalytic activity inhibitor with IC50 of 5/1/6/9 nM for WNK1/2/3/4, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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WNK463 is the first, potent, selective, and orally bioavailable pan With-No-Lysine (WNK) Kinase catalytic activity inhibitor with IC50 of 5/1/6/9 nM for WNK1/2/3/4, respectively.
WNK463 shows >50% inhibition against only 2 out of 442 human kinases at 10 uM.
WNK463 affects blood pressure and body fluid and electro-lyte homeostasis in rodent models of hypertension.
| M.Wt | 463.4562 | |
| Formula | C21H24F3N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
1H-Imidazole-5-carboxamide, N-(1,1-dimethylethyl)-1-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl]-4-piperidinyl]- |
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1. Yamada K, et al. Nat Chem Biol. 2016 Nov;12(11):896-898.
2. Zhang J, et al. Sci Signal. 2016 Oct 18;9(450):pe3.
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