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Chemical Structure : WNK inhibitor 11
CAS No.: 2123489-30-3
Catalog No.: PC-61064Not For Human Use, Lab Use Only.
WNK inhibitor 11 is a potent, selectiive and orally active inhibitor of WNK1 kinase with IC50 of 6 nM, 1,000-fold selectivity over WNK4 and 57-fold selectivity over WNK2.
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WNK inhibitor 11 (WNK-IN-11) is a potent, selectiive and orally active inhibitor of WNK1 kinase with IC50 of 6 nM, 1,000-fold selectivity over WNK4 and 57-fold selectivity over WNK2.
WNK inhibitor 11 shows excellent selectivity with only a few significant off-target kinase inhibitions, most notably BTK and FER kinase.
WNK inhibitor 11 reduces blood pressure in mice overexpressing human WNK1.
WNK inhibitor 11 induces diuresis, natriuresis and kaliuresis in spontaneously hypertensive rats.
| M.Wt | 462.393 | |
| Formula | C21H21Cl2N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(5-chloro-2-(2-(methylamino)thiazol-4-yl)pyridin-4-yl)(4-(4-chlorobenzyl)piperazin-1-yl)methanone |
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1. Yamada K, et al. ACS Chem Biol. 2016 Dec 16;11(12):3338-3346.
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