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WRN inhibitor 40

Chemical Structure : WRN inhibitor 40

CAS No.:

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WRN inhibitor 40

Catalog No.: PC-24739Not For Human Use, Lab Use Only.

WRN inhibitor 40 is a potent, selective and covalent WRN helicase inhibitor with IC50 of 3.7 nM in WRN unwinding assay, targets WRN Cys727.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

WRN inhibitor 40 is a potent, selective and covalent WRN helicase inhibitor with IC50 of 3.7 nM in WRN unwinding assay, targets WRN Cys727.
WRN inhibitor 40 demonstrates selective anti-proliferative activity in WRN dependent cell lines but not in DLD1 cells, with IC50 of 90 nM for SW48 cells.

Physicochemical Properties

M.Wt 788.89
Formula C40H52F4N6O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3R,4S)-N-((R)-3-Cyclohexyl-1-(dimethylamino)-1-oxopropan-2-yl)-1-(2-(2-fluoro-4-(trifluoromethyl)phenyl)acetyl)-4-(3-(5-(2-hydroxy-2-methylpropyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propanamido)piperidine-3-carboxamide

References

1. Yunsong Tong, et al. J Med Chem. 2025 Jun 5. doi: 10.1021/acs.jmedchem.4c03029.

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