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Chemical Structure : WS-12
Catalog No.: PC-60786Not For Human Use, Lab Use Only.
A potent, selective TRPM8 agonist with EC50 of 12 uM, a cooling agent.
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A potent, selective TRPM8 agonist with EC50 of 12 uM, a cooling agent; displays higher potency and efficacy compared to menthol (EC50=193 uM), does activates thermo-sensitive TRP ion channel including TRPV1, TRPV2, TRPV3, TRPV4 and TRPA1 at 1 mM; accelerates skin permeability barrier recovery, also reduces epidermal proliferation associated with barrier disruption.
| M.Wt | 289.41 | |
| Formula | C18H27NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sherkheli MA, et al. J Pharm Pharm Sci. 2010;13(2):242-53.
2. Anand U, et al. Mol Pain. 2010 Nov 24;6:82.
3. Denda M, et al. Exp Dermatol. 2010 Sep;19(9):791-5.
4. Gardiner JC, et al. Eur J Pharmacol. 2014 Oct 5;740:398-409.
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