Catalog No.: PC-38778Not For Human Use, Lab Use Only.
WSB1 inhibitor 4 is a small molecule inhibitor and degarder of the ubiquitin ligase subunit WD repeat and SOCS box-containing 1 (WSB1), displays migration inhibitory activity against WSB1-overexpressing cells.
WSB1 inhibitor 4 is a small molecule inhibitor and degarder of the ubiquitin ligase subunit WD repeat and SOCS box-containing 1 (WSB1), displays migration inhibitory activity against WSB1-overexpressing cells.
WSB1 inhibitor 4 inhibited cell migration through elevating the levels of RhoGDI2 protein, inhibited WSB1-mediated metastasis of cancer cells.
WSB1 inhibitor 4 functions as a WSB1 degrader.
WSB1 inhibitor 4 showed promising pharmacokinetic profiles and an excellent effect in reducing the number of metastatic colonies in vivo.
Physicochemical Properties
M.Wt
334.419
Formula
C21H22N2O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
5,6-bis(4-methoxy-3-methylphenyl)pyridin-2-amine
References
1. Che J, et al. J Med Chem. 2021 Jun 24;64(12):8621-8643.
