WX-02-16

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Chemical Structure : WX-02-16

Catalog No.: PC-27911Not For Human Use, Lab Use Only.

WX-02-16 is an enantioselective covalent inhibitor of BAX, dose-dependently suppresses tBID-triggered, BAX-mediated mitochondrial cytochrome c release, shows covalent engagement of BAX Cys126, protects cells from BAX-dependent apoptosis in HCT116 cells and primary DRG neurons.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

WX-02-16 is an enantioselective covalent inhibitor of BAX, dose-dependently suppresses tBID-triggered, BAX-mediated mitochondrial cytochrome c release, shows covalent engagement of BAX Cys126, protects cells from BAX-dependent apoptosis in HCT116 cells and primary DRG neurons.

Physicochemical Properties

M.Wt	431.49
Formula	C25H25N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,3S)-2-acryloyl-1-(benzo[d][1,3]dioxol-5-yl)-N-propyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide

References

1. Shi P, et al. Nat Chem Biol. 2026 Aug 28. doi: 10.1038/s41589-026-02297-9.

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WX-02-16

Biological Activity

Physicochemical Properties

References

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