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Chemical Structure : WX-02-23
Catalog No.: PC-22145Not For Human Use, Lab Use Only.
WX-02-23 is a covalent small molecule ligand of transcription factor FOXA1 with EC50 of 2 uM in NanoBRET assay, binds cysteine (C258) and promotes the stereoselective and site-specific binding of FOXA1 to DNA.
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WX-02-23 is a covalent small molecule ligand of transcription factor FOXA1 with EC50 of 2 uM in NanoBRET assay, binds cysteine (C258) and promotes the stereoselective and site-specific binding of FOXA1 to DNA.
WX-02-23 stereoselectively blocks CJR-6A reactivity with purified MBP-FOXA1-FKHD protein in the presence of oligonucleotide with IC50 of 8 uM.
WX-02-23 causes the rapid redistribution of FOXA1 across chromatin.
| M.Wt | 459.50 | |
| Formula | C26H25N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Won SJ, et al. bioRxiv. 2024 Mar 21:2024.03.21.586158.
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