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Chemical Structure : WX-554
Catalog No.: PC-63100Not For Human Use, Lab Use Only.
WX-554 is an oral, small molecule allosteric inhibitor targeting mitogen-activated protein kinase kinase (MEK1 and MEK2) with an estimated IC50 of 4.7 and 10.7 nM, respectively.
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WX-554 is an oral, small molecule allosteric inhibitor targeting mitogen-activated protein kinase kinase (MEK1 and MEK2) with an estimated IC50 of 4.7 and 10.7 nM, respectively; exhibits marked synergistic growth inhibition in vitro, which is associated with increased cytotoxicity and enhanced inhibition of ERK and S6 phosphorylation.
Solid Tumors
Phase 1 Discontinued
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| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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