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Chemical Structure : WYE-354
CAS No.: 1062169-56-5
Catalog No.: PC-42848Not For Human Use, Lab Use Only.
WYE-354 is a potent, selective and ATP-competitive inhibitor of mTOR with IC50 of 5 nM (recombinant mTOR ), displays >100-fold selectivity over PI3K isofoms.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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WYE-354 is a potent, selective and ATP-competitive inhibitor of mTOR with IC50 of 5 nM (recombinant mTOR ), displays >100-fold selectivity over PI3K isofoms.
WYE-354 acutely blocks substrate phosphorylation by mTORC1 and mTORC2 in vitro and in cells in response to growth factor, amino acids, and hyperactive PI3K/AKT.
WYE-354 reduces AKT downstream function and inhibits proliferation of diverse cancer cell lines.
WYE-354 inhibits mTORC1 and mTORC2 and displayed robust antitumor activity in PTEN-null tumors.
| M.Wt | 495.5309 | |
| Formula | C24H29N7O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 26 mg/mL |
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| Chemical Name/SMILES |
1-Piperidinecarboxylic acid, 4-[6-[4-[(methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, methyl ester |
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1. Yu K, et al. Cancer Res. 2009 Aug 1;69(15):6232-40.
2. Wahdan-Alaswad RS, et al. Mol Cancer Res. 2012 Jun;10(6):821-33.
3. Weber H, et al. Oncotarget. 2015 Oct 13;6(31):31877-88.
4. Liu Q, et al. J Biol Chem. 2012 Mar 23;287(13):9742-52.
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