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Chemical Structure : Withaferin A
CAS No.: 5119-48-2
Catalog No.: PC-62155Not For Human Use, Lab Use Only.
Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity, potently inhibits NF-κB activation by preventing the TNF-induced activation of IKKβ via a thioalkylation-sensitive redox mechanism.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $458 | In stock | |
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Withaferin A is a steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity, potently inhibits NF-κB activation by preventing the TNF-induced activation of IKKβ via a thioalkylation-sensitive redox mechanism.
Withaferin A potently inhibits the chymotrypsin-like activity of a purified rabbit 20S proteasome (IC50=4.5 uM) and 26S proteasome in human prostate cancer cultures (at 5-10 uM) and xenografts (4-8 mg/kg/day), inhibits cell proliferation in HUVECs (IC50 =12 nM).
| M.Wt | 470.6 | |
| Formula | C28H38O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone |
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1. Falsey RR, et al. Nat Chem Biol. 2006 Jan;2(1):33-8.
2. Kaileh M, et al. J Biol Chem. 2007 Feb 16;282(7):4253-64.
3. Yang H, et al. Mol Pharmacol. 2007 Feb;71(2):426-37.
4. Mohan R, et al. Angiogenesis. 2004;7(2):115-22.
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