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Chemical Structure : X15695
Catalog No.: PC-20995Not For Human Use, Lab Use Only.
X15695 is a potent, selective and orally active estrogen receptor alpha (ERα) degrader, destabilizes ERα and stabilizes p53, inhibits ER+ breast cancer cell growth.
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X15695 is a potent, selective and orally active estrogen receptor alpha (ERα) degrader, destabilizes ERα and stabilizes p53, inhibits ER+ breast cancer cell growth.
X15695 efficiently degrades ERα and attenuates estrogen-mediated target gene expression as well as transactivation by the AR.
X15695 reactivates p53, also disrupts key cellular protein–protein interactions such as BAG1–mortalin (GRP75) interaction as well as wild-type p53–mortalin or mutant p53–BAG2 interactions.
X15695 induces cell-cycle arrest and inhibits proliferation of AR+ and ER+ prostate and breast cancer cells.
X15695 (30 mg/kg/day, oral) effectively inhibited tumor growth in mouse tumor xenograft experiments using LAPC-4 cells.
X15695 is selective for ER+ breast cancer, with no any significant effect on the other tumors cell lines.
| M.Wt | 314.67 | |
| Formula | C14H7ClF4N2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mengwu Pan, et al. Cancer Res Commun. 2023 Jul 27;3(7):1378-1396.
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