X20404 | Mtb Pks13 inhibitor | Probechem Biochemicals

Chemical Structure : X20404

X20404 (X-20404)

Catalog No.: PC-22093Not For Human Use, Lab Use Only.

X20404 is a small molecule inhibitor of the thioesterase activity of Mtb polyketide synthase 13 (Pks13) with IC50 of 0.4 uM in the Pks13-TE enzyme assay.

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Biological Activity

X20404 is a small molecule inhibitor of the thioesterase activity of Mtb polyketide synthase 13 (Pks13) with IC50 of 0.4 uM in the Pks13-TE enzyme assay.
X20404 has a favorable pharmacokinetic profile and demonstrated efficacy in an acute mouse model of tuberculosis (TB) infection.

Physicochemical Properties

M.Wt	457.53
Formula	C26H27N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(4-(6-(2,5-dimethoxyphenyl)pyridin-3-yl)-1H-1,2,3-triazol-1-yl)ethyl)-N,N-dimethylbenzamide

References

1. Krieger IV, et al. ACS Infect Dis. 2024 Apr 5. doi: 10.1021/acsinfecdis.3c00592.

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X20404 (X-20404)

Biological Activity

Physicochemical Properties

References

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