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XF-73

Chemical Structure : XF-73

CAS No.: 718638-68-7

XF-73 (Exeporfinium chloride)

Catalog No.: PC-63533Not For Human Use, Lab Use Only.

XF-73 (Exeporfinium chloride) is a novel broad-spectrum antibacterial agent that inhibits a range of gram-positive bacterial species (MIC=0.25-4 mg/mL), including Staphylococcus aureus.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

XF-73 (Exeporfinium chloride) is a novel broad-spectrum antibacterial agent that inhibits a range of gram-positive bacterial species (MIC=0.25-4 mg/mL), including Staphylococcus aureus; inhibits DNA, RNA and protein synthesis and is rapidly bactericidal against S. aureus SH1000, exhibits rapid membrane-perturbing activity.

Bacterial Infection

Phase 2 Clinical

Physicochemical Properties

M.Wt 765.824
Formula C44H50Cl2N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-Propanaminium, 3,3'-[21H,23H-porphine-5,15-diylbis(4,1-phenyleneoxy)]bis[N,N,N-trimethyl-, dichloride (9CI)

References

1. Ooi N, et al. J Antimicrob Chemother. 2009 Oct;64(4):735-40.

2. Ooi N, et al. J Antimicrob Chemother. 2010 Jan;65(1):72-8.

3. Farrell DJ, et al. Int J Antimicrob Agents. 2010 Jun;35(6):531-6.

4. Farrell DJ, et al. Antimicrob Agents Chemother. 2011 Mar;55(3):1177-81.

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