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XMD16-5

Chemical Structure : XMD16-5

CAS No.: 1345098-78-3

XMD16-5

Catalog No.: PC-42339Not For Human Use, Lab Use Only.

XMD16-5 is a potent Ack1 (TNK2) inhibitor with IC50 of 0.38 uM in ELISA assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

XMD16-5 is a potent Ack1 (TNK2) inhibitor with IC50 of 0.38 uM in ELISA assay; exhibits potent inhibition of growth of the TNK2 mutant expressing cell lines with IC50s of 16 nM and 77 nM for the D163E and R806Q mutations.

Physicochemical Properties

M.Wt 416.47566
Formula C23H24N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 29 mg/mL

Chemical Name/SMILES

6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-11-methyl-

References

1. Miduturu CV, et al. Chem Biol. 2011 Jul 29;18(7):868-79.

2. Maxson JE, et al. Cancer Res. 2016 Jan 1;76(1):127-38.

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