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Chemical Structure : XRK3F2
CAS No.: 2375193-43-2
Catalog No.: PC-61297Not For Human Use, Lab Use Only.
XRK3F2 is a specific ZZ-domain of ubiquitin-binding protein p62 (Sequestosome 1) inhibitor that inhibits MM cell growth and BMSC growth enhancement of human MM cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 25 mg | $198 | In stock | |
| 100 mg | $488 | In stock | |
| 1 g | Get quote |
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XRK3F2 is a specific ZZ-domain of ubiquitin-binding protein p62 (Sequestosome 1) inhibitor that inhibits MM cell growth and BMSC growth enhancement of human MM cells.
XRK3F2 inhibits TNFα-induced osteoclast formation, and has IC50 of 4.35 uM 5TGM1 cells and 4.6 uM for the human MM1.S cell line.
XRK3F2 induces new cortical bone formation in MMBD in vivo, and alters MM cell-BMSC cell interactions by reducing MM cell-derived TNFα in the myeloma microenvironment.
| M.Wt | 435.896 | |
| Formula | C23H24ClF2NO3 | |
| CAS No. | 2375193-43-2 | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name |
2-((3,4-bis((4-fluorobenzyl)oxy)benzyl)amino)ethan-1-ol hydrochloride |
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1. Teramachi J, et al. Leukemia. 2016 Feb;30(2):390-8.
2. Adamik J, et al. Front Endocrinol (Lausanne). 2018 Jun 29;9:344.
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