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Chemical Structure : XX-650-23
Catalog No.: PC-61254Not For Human Use, Lab Use Only.
XX-650-23 is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression.
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XX-650-23 is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression; suppresses AML cell lines growth with IC50 of 0.87-2.3 uM, specifically disrupts CREB-driven transcription, induces apoptosis and cell-cycle arrest; significantly increases survival of cell line- and patient-derived xenograft mice with no toxicity to normal hematopoietic cells or animals.
| M.Wt | 288.306 | |
| Formula | C18H12N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mitton B, et al. Leukemia. 2016 Dec;30(12):2302-2311.
2. François S, et al. J Virol. 2016 Sep 12;90(19):8686-97.
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