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Xeruborbactam disodium

Chemical Structure : Xeruborbactam disodium

CAS No.: 2170848-99-2

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Xeruborbactam disodium (QPX7728 disodium)

Catalog No.: PC-24195Not For Human Use, Lab Use Only.

Xeruborbactam (QPX7728) disodium is an ultrabroad-spectrum beta-lactamase inhibitor, inhibits class A extended-spectrum beta-lactamases with IC50 of 1-3 nM, carbapenemases such as KPC (IC50, 2.9 nM), class C P99 (IC50, 22 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Xeruborbactam (QPX7728) disodium is an ultrabroad-spectrum beta-lactamase inhibitor, inhibits class A extended-spectrum beta-lactamases with IC50 of 1-3 nM, carbapenemases such as KPC (IC50, 2.9 nM), class C P99 (IC50, 22 nM).

Physicochemical Properties

M.Wt 283.96
Formula C10H8BFO5.2Na
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

C([O-])(=O)C1=C2C([C@@]3([C-](C3)([B+3]([OH-])([OH-])[O-]2)[H])[H])=CC=C1F.[Na+]

References

1. Hecker SJ, et al. J Med Chem. 2020 Jul 23;63(14):7491-7507.

2. Lomovskaya O, et al. Antimicrob Agents Chemother. 2021 May 18;65(6):e00210-21.

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