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Chemical Structure : Y16
CAS No.: 429653-73-6
Catalog No.: PC-43137Not For Human Use, Lab Use Only.
Y16 (RhoA-LARG inhibitor Y16) is a small-molecule inhibitor that specifically inhibits LARG binding to RhoA, binds to the junction site of the DH-PH domains of LARG with Kd of 80 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $298 | In stock |
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Y16 (RhoA-LARG inhibitor Y16) is a small-molecule inhibitor that specifically inhibits LARG binding to RhoA, binds to the junction site of the DH-PH domains of LARG with Kd of 80 nM.
Y16 does not affect RhoA interaction with DBL or LBC, also not interfere with the binding of Cdc42 and Rac1.
Y16 suppresses LARG catalyzed RhoA activation dose dependently, selectively inhibits serum-induced RhoA activity and RhoA-mediated signaling.
Y16 inhibits mammary sphere formation of MCF7 breast cancer cells but does not affect the nontransforming MCF10A cells, also works synergistically with Rhosin/G04;
| M.Wt | 384.4272 | |
| Formula | C24H20N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3,5-Pyrazolidinedione, 4-[[3-[(3-methylphenyl)methoxy]phenyl]methylene]-1-phenyl- |
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1. Shang X, et al. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60.
2. Zhang XE, et al. PLoS One. 2016 May 17;11(5):e0155490.
3. Chen W, et al. Int J Biochem Cell Biol. 2017 Dec;93:12-24.
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