Catalog No.: PC-27879Not For Human Use, Lab Use Only.
YCH1899 is a potent, new-generation antiresistant PARP inhibitor with IC50 of <0.001 nM for PARP1/2, exhibits antiproliferation activity against olaparib- and talazoparib-resistant cells with IC50 of 0.89 and 1.13 nM, respectively.
YCH1899 is a potent, new-generation antiresistant PARP inhibitor with IC50 of <0.001 nM for PARP1/2, exhibits antiproliferation activity against olaparib- and talazoparib-resistant cells with IC50 of 0.89 and 1.13 nM, respectively. YCH1899 retained sensitivity in drug-resistant cells with BRCA1/2 restoration or 53BP1 loss. YCH1899 showed prominent dose-dependent antitumor activity in olaparib- and talazoparib-resistant cell-derived xenograft models. YCH1899 activates type I interferon signaling and synergizes with STING agonists in BRCA-proficient tumors.
