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Chemical Structure : YH18968
Catalog No.: PC-20430Not For Human Use, Lab Use Only.
YH18968 is a novel potent, selective GPR119 receptor agonist, potently induces intracellular cAMP accumulation with EC50 of 2.8 nM.
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YH18968 is a novel potent, selective GPR119 receptor agonist, potently induces intracellular cAMP accumulation with EC50 of 2.8 nM.
YH18968 activated human GPR119 approximately 4-fold more potently than MBX2982.
YH18968 elicited dose-dependent increases in insulin release from HIT-T15 cells with EC50 of 3.5 nM.
YH18968 mediated the dual functional activity of GLP-1 secretion and GSIS at the cellular level.
YH18968 (10 mg/kg, oral) improved glucose tolerance in normal C57BL/6J mice.
| M.Wt | 545.58 | |
| Formula | C27H28FN9O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Taedong Han, et al. Biomol Ther (Seoul). 2018 Mar 1;26(2):201-209.
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