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Chemical Structure : YIR-819 TFA salt
Catalog No.: PC-62778Not For Human Use, Lab Use Only.
YIR-819 is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.6 uM against YTA48P virus with no significant cytotoxicity (CC50=33 uM).
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YIR-819 is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.6 uM against YTA48P virus with no significant cytotoxicity (CC50=33 uM); A useful lead compound for the further development of HIV-1 entry inhibitors and could potentially be useful for co-administration with neutralizing antibodies for the treatment of HIV infection and AIDS.
| M.Wt | 606.044 | |
| Formula | C25H35ClF3N7O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ohashi N, et al. ChemMedChem. 2016 Apr 19;11(8):940-6.
2. Boonstra A, et al. Antivir Ther. 2012;17(4):657-67.
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