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Chemical Structure : YKL-1-116
Catalog No.: PC-60961Not For Human Use, Lab Use Only.
YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs.
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YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs.
YKL-1-116 synergizes with 5-FU or nutlin-3 to kill HCT116 cells, produces dose-dependent increases in PARP cleavage.
YKL-1-116 is more potent than THZ1 towards both Cdk7WT and Cdk7as (analog-sensitive mutant).
| M.Wt | 606.731 | |
| Formula | C34H38N8O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kalan S, et al. Cell Rep. 2017 Oct 10;21(2):467-481.
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