YL-IPA08

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Chemical Structure : YL-IPA08

Catalog No.: PC-24504Not For Human Use, Lab Use Only.

YL-IPA08 is a potent and selective TSPO ligand with high affinity (IC50 = 0.23 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

YL-IPA08 is a potent and selective TSPO ligand with high affinity (IC50 = 0.23 nM).
YL-IPA08 produced significant antidepressant-like and anxiolytic-like effects in a series of mouse and rat behavior models, antidepressant-like behavior of YL-IPA08 was totally blocked by the TSPO antagonist PK11195.
YL-IPA08 had no myorelaxant effects and did not affect the motor coordination, memory or hexobarbitone-induced sleep in mice.

Physicochemical Properties

M.Wt	475.80
Formula	C23H21Cl3N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(3,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyridin-3-yl)-N-ethyl-N-(pyridin-2-yl)acetamide hydrochloride

References

1. Zhang LM, et al. Neuropharmacology. 2014 Jun;81:116-25.

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YL-IPA08

Biological Activity

Physicochemical Properties

References

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