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Chemical Structure : YLC2-155
Catalog No.: PC-61948Not For Human Use, Lab Use Only.
YLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT.
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YLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT.
YLC2-155 binds at the RNase H (RNH)-active site in multiple conformations.
YLC2-155 demonstrates inhibition of fully infectious HIV-1 (strain NL4-3) with EC50 of 6.7 uM in cell-based assays.
| M.Wt | 243.22 | |
| Formula | C13H9NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kirby KA, et al. Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01351-17.
2. Kirby KA, et al. Antimicrob Agents Chemother. 2012 Apr;56(4):2048-61.
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