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Chemical Structure : YM-1
Catalog No.: PC-62198Not For Human Use, Lab Use Only.
YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM.
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YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM; enhances client protein ubiquitination and polyQ AR degradation; alleviates toxicity in a Drosophila model of spinobulbar muscular atrophy (SBMA); also disrupts the Hsp70-Bag3 interaction with IC50 of 5 uM.
| M.Wt | 417.97 | |
| Formula | C20H20ClN3OS2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang AM, et al. Nat Chem Biol. 2013 Feb;9(2):112-8.
2. Morishima Y, et al. Biochemistry. 2011 Aug 23;50(33):7146-56.
3. Colvin TA, et al. Cancer Res. 2014 Sep 1;74(17):4731-40.
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