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Chemical Structure : YM-344031
Catalog No.: PC-20726Not For Human Use, Lab Use Only.
YM-344031 is a potent, selective, brain-penetrable CCR3 antagonist with binding IC50 of 3.0 nM, inhibits ligand-induced Ca(2+) flux with IC50 of 5.4 nM.
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YM-344031 is a potent, selective, brain-penetrable CCR3 antagonist with binding IC50 of 3.0 nM, inhibits ligand-induced Ca(2+) flux with IC50 of 5.4 nM.
YM-344031 potently inhibits chemotaxis of human CCR3-expressing cells with IC50 of 19.9 nM.
YM-344031 (1-10mg/kg) orally administered to cynomolgus monkeys significantly inhibited Eotaxin-1-induced eosinophil shape change in whole blood.
YM-344031 (100mg/kg, oral) prevented both immediate- and late-phase allergic skin reactions in a mouse allergy model.
YM-344031 (50 mg/kg, b.i.d.) attenuated neurodegenerative pathologies and improves learning and memory performance in a mouse model of Alzheimer's disease, resulted in dramatic decreases in β-amyloid deposition, tau hyperphosphorylation and synaptic loss in the forebrain.
| M.Wt | 502.59 | |
| Formula | C29H31FN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Suzuki K, et al. Biochem Biophys Res Commun. 2006 Jan 27;339(4):1217-23.
2. Sui Y, et al. Brain Res. 2019 Sep 15;1719:1-10.
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