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Chemical Structure : YM116
Catalog No.: PC-63002Not For Human Use, Lab Use Only.
YM116 is a potent CYP17A1 (17,20-lyase) inhibitor with IC50 with Ki of 0.38 nM, inhibits C17-20 lyase activity in human testicular microsomes with IC50 of 4.2 nM.
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YM116 is a potent CYP17A1 (17,20-lyase) inhibitor with IC50 with Ki of 0.38 nM, inhibits C17-20 lyase activity in human testicular microsomes with IC50 of 4.2 nM; inhibits cortisol production with IC50 of 50.4 nM, decreases the serum testosterone concentration in gonadotropin-releasing hormone-treated rats (ED50=0.7 mg/kg); also reduces dehydroepiandrosterone sulfate levels in ACTH-treated castrated rats (ED50=11 mg/kg).
Prostate Cancer
Phase 1 Discontinued
| M.Wt | 247.301 | |
| Formula | C16H13N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ideyama Y, et al. Prostate. 1998 Sep 15;37(1):10-8.
2. Ideyama Y, et al. Jpn J Pharmacol. 1999 Feb;79(2):213-20.
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