Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : YM543
Catalog No.: PC-60987Not For Human Use, Lab Use Only.
A potent, selective and orally active SGLT2 inhibitor with IC50 of 8.9 nM, 280-fold selectivity over SGLT1.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent, selective and orally active SGLT2 inhibitor with IC50 of 8.9 nM, 280-fold selectivity over SGLT1; dose-dependently and significantly reduces blood glucose levels and improves glucose tolerance with a concomitant increase in urinary glucose excretion, also significantly reduces hyperglycemia in type 2 diabetic mice.
Diabetes
Phase 2 Clinical
| M.Wt | 500.611 | |
| Formula | C28H38NO7+ | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Yokono M, et al. Endocr Res. 2013 Feb 1.
2. Ikegai K, et al. Bioorg Med Chem. 2013 Jul 1;21(13):3934-48.
3. Nakada N. Pharm Res. 2017 Apr;34(4):874-886.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
