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Chemical Structure : YQ-0629
Catalog No.: PC-72532Not For Human Use, Lab Use Only.
YQ-0629 is a specific HIF-2α inhibitor, binds to HIF-2α PAS-B domain with Kd of 57.5 uM.
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YQ-0629 is a specific HIF-2α inhibitor, binds to HIF-2α PAS-B domain with Kd of 57.5 uM.
YQ-0629 could inhibit the expression of HIF-2α with or without the presence of PTX (3 nM) in MCF7 MS culture, does not bind to HIF-1α or affect the expression of HIF-1α.
YQ-0629 suppresses self-renewal capacity and synergizes with PTX to reverse the chemoresistance of MCF7 MS.
YQ-0629 inhibits growth of BCSCs derived from breast cancer patients and synergistically increases anti-BCSCs activity of PTX in vivo.
| M.Wt | 359.429 | |
| Formula | C22H21N3O2 | |
| Appearance | Solid | |
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1. Yan Y, et al. Cell Death Differ. 2022 Mar 17. doi: 10.1038/s41418-022-00963-8.
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