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Chemical Structure : YQ128
CAS No.: 2454246-18-3
Catalog No.: PC-21694Not For Human Use, Lab Use Only.
YQ128 is potent, second-generation inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome with IC50 of 0.3 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $368 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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YQ128 is potent, second-generation inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome with IC50 of 0.3 uM.
YQ128 dose dependently suppresses the release of IL-1β from peritoneal macrophages upon LPS/ATP challenge with IC50 of 1.59 uM.
YQ-128 (10 mg/kg) inhibits LPS-induced IL-1β production in wild-type but not Nlrp3-/- mice.
| M.Wt | 545.11 | |
| Formula | C27H29ClN2O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl]phenyl]ethyl]-3-thiopheneacetamide |
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1. Yuqi Jiang, et al. J Med Chem. 2019 Nov 14;62(21):9718-9731.
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